Figure 3: Ortho-proteogenomics: extending proteogenomic annotation to closely-related genomes. Colored arrows represent coding ORFs in sequenced genomes from six related- species. Black rectangles beneath these ORFs in species 1 represent the peptides detected by tandem mass spectrometry through its proteome analysis. Two cases of miss-annotations were corrected in Species 1 and are indicated by red arrows. These corrections can be then extended to the other five species because of the conservation of the whole locus in most cases (grey vertical rectangles).