| Molecular weight in kD |
Antigen |
Meaning for diagnosis |
Antibody reactions |
| p100/p83 |
(p83 is degradation product of p100) |
+++ |
Typically positive in late stages, but early antibody reaction possible |
| p58 |
|
+ |
Often in stage 3 |
| p43/p45 |
|
+ |
Mostly in stage 3 |
| p41 |
Flagellin |
+ |
Very early reactive, cross reactions with some antigen preparations |
| p39 |
BmpA
(Borrelial membrane protein A) |
+++ |
Rather specific for late IgG-response; sometimes also early |
| p31 |
OspA (Outer surface protein A) |
++ |
Late response |
| p30 |
|
+ |
Not clearly defined |
| p22/p25 |
OspC |
+++ |
Very early seen; mostly the first specific reaction of the early IgM response; species specific, especially the IgG response |
| p21 |
OspC-Homolog |
++ |
Early stage |
| p19 |
OspE |
+ |
Not clearly defined |
| p18 |
Dbp (A)
Decorin binding protein A |
++ |
Surface protein, species specific response |
| p17 |
Osp17 |
+ |
Not B. burgdorferi sensu strictu and B. garinii |
| p14 |
internal protein |
+ |
Mostly in early infection |
| VlsE |
VlsE=vmp (variable major protein) like sequence expressed, surface lipoprotein |
|
IgG in early and late infection, intra thecal IgM response in neuroborreliosis |
