IgM IgG Interpretation
Screening Confirmation Screening Confirmation  
neg neg neg neg No late Borreliosis; no acute infection (CAVE: very early infection with negative serology; depending on the clinical situation a control in 10-14 days should be recommended)
pos neg pos neg Unspecific reactions; the interpretation of the serological result has to be “negative” (CAVE: very early infection with positive screening test but negative confirmation test; depending on the clinical situation a control in 10-14 days should be recommended)
pos pos neg neg Early infection (CAVE persisting IgM from a former infection without IgG-production)
pos pos pos pos Early infection with IgG already positive (CAVE: former infection with persistent IgM)
neg neg pos pos Active infection stage 2 or 3 or persistent IgG after spontaneous healing or sucessfull treatment
Table 4: Interpretation of typical serological antibody constellations.