Challenge Virus Vaccine platform Test Species References
VEEV Adenovirus Mice (BALB/c) [65,66,68,85]
Equine Herpesvirus type I Mice (NIH Swiss) [71]
Vaccinia virus Mice (NIH Swiss, A/J, C3H, BALB/c) [77-80]
DNA Mice (BALB/c), rabbit, NHP [81-85]
SINV/VEEV Chimeras Mice (NIH Swiss), Hamster [31,32]
VRP Mice (BALB/c), NHP P Glass, D Reed, manuscript in preparation
Attenuated (furin cleavage site mutant) Mice (BALB/c, CH3, C57BL/6, CD-1), hamster, Horse, NHP [42-48]
Attenuated and Inactivated Mice (BALB/c, CD-1) [49-52]
Subunit Mice (BALB/c, NIH Swiss) [89,90]
WEEV Adenovirus Mice (BALB/c) [16,69,70]
SINV/WEEV Chimera Mice (NIH Swiss) [33,34]
DNA Mice (BALB/c) [15,86]
Attenuated (furin cleavage site mutant) Chickens [41]
Subunit Mice (BALB/c) [87,88]
EEEV SINV/EEEV Chimeras Mice (NIH Swiss) [35,36]
Attenuated and Inactivated Mice (BALB/c) P Glass, personal communication
Table 2: Summary of select alphavirus vaccine studies.