Figure 1: Survival curves and weight loss post challenge in vaccinated guinea pigs with or without DEF201 treatment. A) Protective efficacy of Ad-CAGoptZGP with or without DEF201 in female Hartley guinea pigs and B) their associated weight loss curves. Groups of 3 or 6 guinea pigs were challenged intraperitoneally with 100 x LD50 of guinea pig-adapted Zaire Ebola virus and treated intramuscularly with Ad-CAGoptZGP at 1 x 1010 IFU per animal in conjunction with the specified treatment 30 minutes post-challenge. Data represents percentage survival or percentage weight loss respectively.