Figure 3: Survival curves and weight loss post challenge in mice. A) Protective efficacy of Ad-CAGoptZGP in B10.BR mice and B) their associated weight loss curves. Groups of 5 or 10 mice were challenged intraperitoneally with 1000 x LD50 of mouse-adapted Zaire Ebola virus and treated intramuscularly or intranasally with 1 x 107 IFU DEF201 per animal, or intramuscularly with AdHu5-empty at 1 x 107 IFU per animal 30 minutes post-challenge. Data represents percentage survival or percentage weight loss respectively.