Figure 5: Humoral immune responses in vaccinated mice with or without DEF201 treatment. A) Serum ZEBOV GP-specific IgG ELISAs. The harvested serum samples were also tested for the presence of IgG antibodies against ZEBOV GP at a 1:50 dilution ratio. The data is reported as the optical density measured by absorbance at 405nm. B) Serum ZEBOV GP-specific neutralizing antibody response. Groups of 3 to 6 mice were vaccinated and treated with or without DEF201, where serum was harvested 28 days post-vaccination. Serum neutralizing antibody levels were reported as the reciprocal of the dilution where greater than 50% viral neutralization was observed.