Figure 5: The total platinum concentration-time profile in plasma.
Cisplatin and dendrimer-cisplatin complexes (G4 NH2 and Biotin G4 NH2) were administered intraperitoneally at 4 mg/kg dose and plasma was isolated from blood collected from mice at 4 and 24 hrs after administration. The collected plasma after treatment with HNO3 was analyzed for platinum using ICP-MS. Results were compared using one-way ANOVA and F<0.05 was considered significant.