group Description Findings 1 surgical procedure Inflammation associated to injection 2 Tumor 17% survival. Fast cell proliferation, inflammation and highly invasive cell behaviour 3 Tumor+MTX 75% of the animals died 33 days later of infiltration. No significant therapeutic effect was observed 4 MTX/SiO2 100% survival. Mild inflammation and macrophages were observed around particles 5 Tumor+ MTX/SiO2 80% survival. Small lesion area, moderate chronic inflammation with abundant macrophages, lymphocytes and hemosiderophages. After 6 months no tumor activity was observed .

Table 3: Summarized in vivo findings.