Name of recombinant antigen Seroreactivity with Y. pestis infected mice sera IgG titer in Y. pestis infected mice IgG isotypes in Y. pestis infected mice YpkA No NSD NSD YopH Yes 1:3200 IgG1, IgG2b YopM Yes 1:3200 NSD V antigen Yes 1:6400 IgG1, IgG2a, IgG2b, IgG3 Pla Yes 1:3200 NSD Yop N No NSD NSD YopJ No NSD NSD YopE Yes 1:6400 IgG1, IgG2b YopK No NSD NSD F1 Yes 1:6400 IgG1, IgG2a, IgG2b, IgG3 pH6 antigen No NSD NSD NSD: No significant difference

Table 3: Summary of recombinant antigens of Y. pestis (Indian isolate) and their relative immune response in experimental infected Balb/C mice.