Analyte M1 (pg/mL) M1 + VSL#3 (pg/mL) Fold-Change
Mean ΔCCS 95% CI Mean ΔCCS 95% CI
IL-1α# -0.40 -0.40, -0.40 13.90 11.74, 16.06 35.75
IL-1β * -39.95 -71.41, -8.49 324.90 277.47, 372.33 9.13
IL-4 # -3.95 -4.24, -3.66 8.40 3.89, 12.91 3.13
IL-6 * -1060.76 -2214.73, 93.21 5902.52 3883.72, 7921.32 6.56
IL-17A # -1.80 -3.17, -0.43 -4.05 -4.34, -3.76 2.25
G-CSF * -95.50 -159.20, -31.80 11120.81 10869.93, 11371.69 117.45
MDC x -238.50 -243.40, -233.60 -497.00 -618.52, -375.48 2.08
*Change seen in all macrophage types; # Change seen in this macrophage type only; x Change also seen in MΦ macrophages; Cytokine levels for days 8 and 11 are shown in Supplemental Table 1; Levels for IL-8, IL-10, and TNF-α were above the detection limit at both time points and are therefore not reported.
Table 1: Cytokines differentially secreted by M1 macrophages in response to VSL#3.