Analyte M2 (pg/mL) M2 + VSL#3 (pg/mL) Fold-Change
Mean ΔCCS 95% CI Mean ΔCCS 95% CI
IL-1β * 0.12 -0.12, 0.36 71.17 70.92, 71.42 593.08
IL-1Ra 187.00 159.56, 214.44 490.00 462.56, 517.44 2.62
IL-2 11.15 9.48, 12.82 0.75 -1.31, 2.81 0.07
IL-6 * 3.15 0.90, 5.40 1813.15 1621.56, 2004.74 575.60
IL-7 2.55 0.49, 4.61 62.60 51.23, 73.97 24.55
IL-8 -23.70 -49.77, 2.37 8367.00 8341.52, 8392.48 354.04
IL-9 0.60 0.50, 0.70 50.78 48.67, 52.88 84.63
IL-10 60.70 44.43, 76.97 9718.39 9701.73, 9735.05 160.11
IL-12p40 4.30 3.12, 5.48 545.15 498.01, 592.29 126.78
IL-12p70 2.90 2.90, 2.90 24.65 23.96, 25.34 8.50
IL-13 6.75 4.30, 3.12 21.15 12.82, 29.48 3.13
IL-15 9.05 3.07, 15.03 24.65 24.36, 24.94 2.72
EGF 1.35 1.25, 1.45 12.80 12.41, 13.19 9.48
Eotaxin 1.40 1.20 1.60 26.45 23.61, 29.29 18.89
FGF-2 4.75 3.67, 5.83 19.35 16.51, 22.19 4.07
Fractalkaline# 96.00 92.08, 99.92 237.50 207.12, 267.88 2.47
G-CSF * 23.60 14.19, 33.01 2134.85 2058.31, 2211.39 90.46
GRO 16.60 10.52, 22.68 4591.80 3891.49, 5292.11 276.61
IFN-α2 10.45 9.18, 11.72 39.50 37.93, 41.07 3.78
MCP-3 276.30 176.93, 375.67 45.65 45.16, 46.14 0.17
MIP-1α 20.65 13.89, 27.41 309.55 300.04, 319.06 14.99
MIP-1β 91.70 45.44, 137.96 980.80 770.30, 1191.30 10.70
TGF-α 33.00 32.22, 33.78 302.85 302.56, 303.14 9.18
TNF-α 17.15 2.35, 31.95 3378.05 3004.77, 3751.33 196.97
VEGF 65.80 56.98, 74.62 7630.30 7455.66, 7804.94 115.96
* Change seen in all macrophage types; # Change seen in this macrophage type only; Cytokine levels for days 8 and 11 are shown in Supplemental Table 2; Levels for IL-4 were above the detection limit at both time points and are therefore not reported
Table 2: Cytokines differentially secreted by M2 macrophages in response to VSL#3.