Analyte MΦ (pg/mL) MΦ + VSL#3 (pg/mL) Fold-Change
Mean ∆CCS 95% CI Mean ∆CCS 95% CI
IL-1β * 0.00 0.00, 0.00 107.64 29.24, 186.04 Undef
IL-1Ra 37.05 32.25, 41.85 291.55 132.30, 450.80 7.87
IL-2 4.45 4.16, 4.74 1.95 1.07, 2.83 0.44
IL-6 * -2.20 -6.12, 1.72 2929.10 1492.81, 4365.39 1332.41
IL-7 -1.45 -3.31, 0.41 58.05 44.23, 71.87 41.03
IL-8 -163.50 -338.92, 11.92 8277.50 8192.24, 8362.76 51.63
IL-9 0.05 0.05, 0.05 3.20 1.93, 4.47 64.00
IL-10 8.85 6.60, 11.10 9727.89 9702.41, 9753.37 1099.20
IL-12p40 2.55 0.30, 4.80 465.45 38.66, 892.24 182.53
IL-12p70 1.10 0.90, 1.30 10.05 6.03, 14.07 9.14
IL-13 0.95 0.85, 1.05 4.70 1.76, 7.64 4.95
IL-15 5.90 4.53, 7.27 19.55 14.94, 24.16 3.31
EGF -0.35 -2.60, 1.90 12.17 8.50, 15.84 35.77
Eotaxin 1.35 0.27, 2.43 27.05 21.86, 32.24 20.04
FGF-2 1.35 -0.12, 2.82 13.45 10.80, 16.10 9.96
G-CSF * 7.15 2.54, 11.76 8030.45 1601.16, 14459.74 1123.14
GM-CSF # 5.20 -0.68, 11.08 83.55 30.34, 136.76 16.07
GRO 28.30 28.10, 28.50 4738.70 3277.52, 6199.88 167.45
IFN-α2 7.35 5.10, 9.60 26.40 25.81, 26.99 3.59
IFN-γ # 2.10 0.92, 3.28 102.70 32.34, 173.06 48.90
MCP-1 # 257.00 241.32, 272.68 -8020.50 -10885.04, -5155.96 32.21
MCP-3 40.80 32.18, 49.42 10.45 -1.60, 22.50 0.26
MDC x 5001.50 4822.16, 5180.84 1046.50 590.80, 1502.20 0.21
MIP-1α 20.25 14.86, 25.64 242.70 78.45, 406.95 11.99
MIP-1β 20.40 11.58, 29.22 140.80 75.14, 206.46 6.90
TGF-α 4.80 4.41, 5.19 34.90 21.18, 48.62 7.27
TNF-α 2.50 2.30, 2.70 1539.65 552.30, 2527.00 615.86
VEGF 13.15 11.29, 15.01 6746.25 3471.38, 10021.12 513.02
* Change seen in all macrophage types; # Change seen in this macrophage type only; x Change also seen in M1 macrophages; Undef = undefined; Cytokine levels for days 8 and 11 are shown in Supplemental Table 3
Table 3: Cytokines differentially secreted by MΦ macrophages in response to VSL#3.