Figure 6: Role of IL23 in skewing of CD4+ cells by premalignant oral lesions and HNSCC. Normal spleen cells were cultured with media conditioned by premalignant lesion cells that had been mixed with isotype control antibody or antiIL23. Alternatively, spleen cells were incubated with media conditioned by HNSCC cells plus recombinant IL23. Shown are representative scattergrams from 4 separate studies.