Figure 4 :5-FU /chamomile e×tract treated group: On day 8, chamomile e×tract reduce villus height atrophy as well as crypt destruction (A1, H&E ×10), most of the cells lining the villi are more or less intact (A2, H&E ×400). Some villi showing changes in the shape with separation of the epithelium from lamina propria (A3, Trichrome ×400). No muscular edema and congested blood vessels are seen (A4, Trichrome ×400). On day 12, the villi are lost in some area, arrow (B1, Trichrome × 40), or show necrosis in other areas (B2, Trichrome × 400). The epithelium of villi may be separated from lamina propria (upper arrow) or lost in other areas, lower arrow (B3, H&E ×400). The muscle layers shows severe edema, arrow (B4, H&E ×400). Mild (arrows) and negative Ki-67 immuno reactivity in nuclei of cells at day eight and twelve respectively (C1, immunohistochemistry ×100, C2, immunohistochemistry ×100). Mild and negative cytoplasmic reaction to Bcl-2 cells at day eight and twelve respectively (C3 immunohistochemistry ×400, C4, immunohistochemistry ×100).