| Peripheral T cell Tolerance |
Modes of Tolerance Breakdown |
|
Immune ignorance |
Release of sequestered antigens
Aberrant expression of MHC class II
Increased expression of autoantigen/MHC class II
Molecular mimicry
Epitope spreading |
|
Anergy |
Release of inflammatory mediators
Increased expression or function of costimulatory molecules
Suppression of IDO |
| Regulatory T Cells |
Release of inflammatory mediators |
|
Apoptosis |
Defects in apoptosis signaling
Viral apoptosis inhibitors
|
