| 
      &Categorical variables are presented using counts and percentages. #Continuous variables: WBC, Neutrophils, Lymphocytes and Monocytes are presented as mean
    (SD); Age, Disease duration, RBC, Eosinophils and Basophils are expressed as median (interquartile range). Denote: a, difference between T1D children and controls;
    b, difference between siblings and controls. *, P < 0.05; **, P < 0.01; *** P < 0.001.
        |  | T1D | Siblings | Controls | Significance Value |  
        | Number | 26 | 32 | 29 |  |  
        | &Male | 15    (58%) | 16    (50%) | 14    (48%) | 0.43 |  
        | #Age (yrs) | 12.25    (6.30) | 11.75    (6.36) | 8.18    (7.74) | 0.25 |  
        | #Disease duration (yrs) | 2.95    (4.45) |  |  |  |  
        | Autoantibody |  
        | &GADA | 15 (83%) | 4 (14%) |  |  |  
        | &IA-2A | 14 (82%) | 1 (4%) |  |  |  
        | &GADA&IA-2A | 14 (82%) | 1 (4%) |  |  |  
        | Blood Count (x106/ml) |  
        | RBC | 4790    (235) | 4670    (360) | 4560    (455) | a* |  
        | #WBC | 6.30 (1.37) | 6.23 (1.34) | 9.05 (3.14) | a***, b*** |  
        | #Lymphocytes | 2.62    (0.89) | 2.58    (0.65) | 3.64    (1.04) | a***,    b*** |  
        | #Monocytes | 0.49    (0.12) | 0.48    (0.10) | 0.64    (0.25) | a**, b*** |  
        | #Neutrophils | 2.87    (0.98) | 2.85    (1.06) | 4.34    (2.33) | a**, b** |  
        | #Eosinophils | 0.20    (0.17) | 0.14    (0.22) | 0.25    (0.36) | 0.26 |  
        | #Basophils | 0.04    (0.04) | 0.04    (0.05) | 0.06    (0.005) | 0.13 |  |