Table 1

Signaling Molecule	Involved in Regulating	Reference #

miR-146a	AICD	[69]
miR-29	Helper T cell differentiation	[69]
miR-155, miR-221	T cell activation	[71,72]
miR-K12-3, miR-K12-7	IL-6 and IL-10 production	[52]
PD-1	T cell exhaustion	[10, 12, 13]
Blimp-1	T cell exhaustion	[19]
CTLA-4,2B4, CD160, GP49B	T cell exhaustion	[10, 22-26]
LAG-3	T cell exhaustion	[10, 22-26]
IRF-3 and Bax	T cell apoptosis	[41, 42]
NS1 protein	host immune system	[44]
NS3/4 A	host immune system	[45]
V protein	T cell apoptosis	[46]
ISG56	IFN1 production	[47]
3Cpro cystein protease	IFN1 production	[48]
TAR miRNA	host ERCC1 and IER3	[51]
CPAF	Bik, Puma and Bim degradation	[54]
TRAF3	T cell activation	[57]
NF-κB, bcl-2	T cell apoptosis	[58]
NF-κB,	cytochrome c T cell apoptosis	[59]
B7-H1	apoptosis of tumor-reactive T cells	[16]
Tim-3	immunosuppression, T cell exhaustion	[60, 10, 25]
Galectin-1	T cell apoptosis	[61]
TRAIL-R1	host immune system	[62]
Fas	host immune system	[63]
STAT-3	immunosurveillance	[65, 66, 67]
IDO	immunosurveillance	[68]
Fas-FasL	T cell apoptosis	[74]
XIAP	apoptosis	[78,79, 82]
Bcl-2, Bcl-XL, Bcl-W	apoptosis	[83]

Table 1: Signaling Molecules and their role in T cell Regulation