| Vaccine Produced |
Host Plant/Expression System Used |
Number of Human Subjects |
Details, Immune Response Obtained |
Reference |
| Norwalk Virus nucleocapsid |
Transgenic Potato |
24 volunteers |
Oral consumption; IgA, IgM and IgG responses detected |
24, 34 |
| LT-B from enterotoxigenic E. coli |
Transgenic Corn |
13 volunteers |
Oral consumption; IgA, IgG response detected |
24, 34 |
| LT-B from enterotoxigenic E.coli |
Transgenic Potato |
14 volunteers |
Oral Consumption; IgA, IgG response detected |
24, 34 |
| HBsAg from Hepatitis B virus |
Transgenic potato |
16 volunteers |
Oral consumption; 10 volunteers exhibited IgG serum response |
36 |
| HBsAg from Hepatitis B virus |
Transgenic Spinach |
3 volunteers |
Oral consumption; 2 exhibited serum IgG response |
31 |
| Glycoprotein from Rabies virus |
Spinach infected with virus vector |
9 volunteers |
Oral consumption; 5 demonstrated serologic IgG response |
63 |
| HA protein of H5N1 Influenza virus |
N. benthamiana infiltrated with vector |
Phase I completed successfully with 48 volunteers, Phase II in progress |
Virus-like particles, delivered by injection, IgG response as determined by hemagglutinin inhibition and neutralization assays |
57 |
| Non-Hodgkin Lymphoma anti-idiotype scFv |
N. benthamiana infiltrated with vector |
Phase I in progress with 16 patients suffering from NHL |
Delivered by injection, 11 had cellular immune response (T cell proliferation) and of these, 7 had a humoral response |
58 |
