| Variables |
Younger <70 years (n=115) |
Elderly ≥70 years (n=111) |
p value |
| Age, years |
59.7 ± 0.88 |
77.1 ± 0.4 |
<0.0001 |
| Male, % |
71.3 % |
63.8 % |
0.31 |
| Smoking status, % |
17.1 % |
3.0 % |
0.0009 |
| BMI, Kg/m2 |
29.6 ± 0.59 |
27.9 ± 0.5 |
0.02 |
| Waist circumference, cm |
104.2 ± 1.59 |
101.4 ± 1.55 |
0.21 |
| Hypertension, % |
56.4 % |
68.9 % |
0.04 |
| Diabetes, % |
23.3 % |
34.3 % |
0.09 |
| Glycemia, mmol/L |
5.87 ± 0.13 |
5.80 ± 0.15 |
0.88 |
| Metabolic syndrome, % |
28.1 % |
23.0 % |
0.43 |
| CAD, % |
66.4 % |
50.0 % |
0.02 |
| Lipids |
| LDL-cholesterol, mmol/L |
2.5 ± 0.08 |
2.1 ± 0.08 |
0.002 |
| HDL-cholesterol, mmol/L |
1.3 ± 0.03 |
1.3 ± 0.04 |
0.85 |
| Triglycerides, mmol/L |
1.58 ± 0.08 |
1.32 ± 0.59 |
0.01 |
| Statines, % |
97.1 % |
96.1 % |
1 |
| ACE inhibitors/ARBs, % |
40.7 % |
47.5 % |
0.33 |
| Bicuspid valve, % |
49.5 % |
7.7 % |
<0.0001 |
| Creatinine, mmol/L |
86.9 ± 1.7 |
97.1 ± 2.4 |
0.0007 |
| CRP, mg/L |
2.45 ± 0.36 |
2.52 ± 0.31 |
0.89 |
| Fetuin A, g/L |
0.46 ± 0.02 |
0.36 ± 0.02 |
0.0006 |
| Preoperative peak transvalvular gradient,
mmHg |
71 ± 3 |
71 ± 2 |
0.5 |
| Preoperative aortic valve area, cm2 |
0.78 ± 0.2 |
0.73 ± 0.18 |
0.1 |
| Annualized peak transvalvular gradient,
mmHg/year |
7.99 ± 0.9 |
9.10 ± 0.8 |
0.38 |
| Annualized aortic valve area, cm2/year |
-0.12 ± 0.1 |
-0.12 ± 0.1 |
0.1 |
| Aortic valve calcium content, mg/ g ww tissue |
56.9 ± 3.86 |
58.7 ± 3.26 |
0.72 |
Legend: BMI: body mass index; CAD: coronary artery disease; LDL: low-density lipoprotein; HDL:
high-density lipoprotein;
ACE: angiotensin-converting enzyme; ARB: angiotensin receptor blockers;
CRP: C-reactive protein. Values are mean ± SEM |
