| 
      
        |  | Baseline (n=81) | Follow-up(n=81) | P value (paired t-test or McNemar test) |  
        | Echocardiographic parameters |  |  |  |  
        | LVEDd/height, mm/m (n=80) | 27.6±2.8 | 27.7±2.7 | 0.71 |  
        | LVESd/height, mm/m (n=79) | 18.5±2.2 | 18.4±1.9 | 0.74 |  
        | LV mass index, g/m2 (n=76) | 44±10 | 45±8 | 0.59 |  
        | EF, % | 59.8±3.9 | 59.1±3.9 | 0.12 |  
        | LA volume index, ml/m2 (n=78) | 22.8±5.5 | 23.7±6.3 | 0.27 |  
        | E, cm/s | 73±17 | 77±18 | 0.095 |  
        | A, cm/s | 72±19 | 77±20 | 0.003 |  
        | E/A | 1.2±1.1 | 1.0±0.3 | 0.17 |  
        | Deceleration time, ms | 210±35 | 204±42 | 0.26 |  
        | e’ lateral, cm/s | 11.4±3.5 | 11.2±2.9 | 0.40 |  
        | E/e’ | 6.9±2.2 | 7.4±2.6 | 0.029 |  
        | Systolic PAP (n=36) | 30±6 | 29±6 | 0.29 |  
        | TAPSE (n=59) | 22±4 | 21±4 | 0.80 |  
        | Right ventricular S’(n=70) | 13±2 | 13±2 | 0.73 |  
        | Global longitudinal strain, % (n=76) | -20.1±2.5 | -20.1±2.4 | 0.93 |  
        | Diastolic function |  |  | 0.44 |  
        | Normal | 46 (56.8%) | 47 (58.0%) |  |  
        | Grade I DD | 33 (40.7%) | 28 (34.6%) |  |  
        | Grade ≥2 DD | 2 (2.5%) | 6 (7.4%) |  |  |