Variables Days Mean ± SD P-value HR (bpm) baseline 214 21 0.261 30 209 26 72 190 51 LVED (ml) baseline 0.51 0.09 0.127 30 0.52 0.12 72 0.59 0.08 LVES (ml) baseline 0.25 0.05 0.048* 30 0.32 0.14 72 0.33 0.05 EF (%) baseline 50.3 4.52 0.03* 30 47.2 5.63 72 45.2 2.66 E (m/s) baseline 0.66 0.13 0.254 30 0.53 0.18 72 0.55 0.20 A (m/s) baseline 0.31 0.03 0.051 30 0.42 0.20 72 0.26 0.15 E/A ratio baseline 2.11 0.44 0.737 30 0.64 0.91 72 1.9 0.35 Tei-index baseline 0.49 0.08 0.544 30 0.44 0.09 72 0.39 0.11

Table 2: Echocardiography data of experimental (Hypo) group. Heart Rate (HR); Left ventricular end-diastolic (LVED); Left ventricular end-systolic (LVES); Ejection function (EF); A wave (A); E wave (E). Data expressed as mean ± SD. P ≤ 0.05.