Clinical situation

Treatment

Third-degree block, no hydrops fetalis

Second-degree block or alternating second/third-degree block

 

Prolonged mechanical PR interval (first-degree block)

 

Block associated with signs of myocarditis, CHF and/or hydropic changes

 

Severely hydropic fetus

Evaluation by serial echocardiography; no therapy.

Administer 4 mg of oral dexamethasone daily. If progression to third-degree block occurs, taper dexamethasone dosage to discontinuation. If reversal to NSR or lesser forms of block occurs, continue to delivery at term.

 

Repeat echocardiography in 24 h. If first-degree block persists, administer 4 mg of oral dexamethasone daily. If progression to third-degree block occurs, taper dexamethasone dosage to discontinuation. If reversal to NSR occurs or first-degree block persists, taper or individualize therapy.

 

Treatment with 4 mg of oral dexamethasone daily until improvement.

Consider termination. Treatment with 4 mg of oral dexamethasone daily and apheresis to rapidly remove maternal antibodies.

CHF: chronic heart failure; NSR: normal sinus rhythm
Table 4: Therapeutic approaches to CHB diagnosed in utero.