| Percentage of filamentation |
| Dose (J) |
Continuous |
2.5 Hz |
250 Hz |
2500 Hz |
| AB1157 |
| 0.13 |
1.7 ± 0.58* |
1.0 ± 0.08* |
4.7 ± 0.58* |
1.7 ± 0.48* |
| 0.52 |
2.0 ± 1.05* |
1.0 ± 0.52* |
4.0 ± 1.00* |
2.0 ± 0.50* |
| 1.04 |
3.7 ± 1.53* |
11.0 ± 1.00* |
12.7 ± 2.08* |
6.0 ± 1.00* |
| BW527 |
| 0.13 |
5.7 ± 0.58* |
4.7 ± 1.15* |
5.7 ±1.43* |
6.0 ± 1.00* |
| 0.52 |
3.3 ± 0.48 |
3.7 ± 0.57 |
3.7 ± 0.59 |
5.3 ± 0.54* |
| 1.04 |
5.3 ± 1.53* |
6.3 ± 1.50* |
7.3 ± 0.60* |
5.3 ± 0.55* |
| BW9091 |
| 0.13 |
63.3 ± 4.16* |
54.3 ± 4.51* |
64.3 ± 5.12* |
24.3 ± 4.93* |
| 0.52 |
86.7 ± 4.93* |
90.3 ± 4.41* |
94.7 ± 2.52* |
32.7 ± 3.79* |
| 1.04 |
78.3 ± 3.06* |
85.7 ± 5.13* |
54.7 ± 4.73* |
81.7 ± 7.09* |
| BH20 |
| 0.13 |
5.3 ± 0.60 |
1.7 ± 0.57 |
3.3 ± 0.54 |
3.0 ± 0.99 |
| 0.52 |
4.3 ± 0.58 |
4.0 ± 1.04 |
2.0 ± 1.00 |
3.3 ± 0.59 |
| 1.04 |
4.0 ± 1.00 |
2.3 ± 1.58 |
2.7 ± 0.68 |
4.0 ± 0.02 |
| BW375 |
| 0.13 |
8.0 ± 2.00* |
5.0 ± 1.00 |
6.7 ± 1.14 |
6.0 ±1.00 |
| 0.52 |
7.3 ± 0.60* |
7.0 ± 1.01* |
6.0 ± 1.98* |
8.3 ± 0.48* |
| 1.04 |
12.0 ± 2.00* |
8.7 ± 1.15* |
8.0 ± 1.02* |
8.0 ± 2.05* |
Controls: 0.1 ± 0.04 for AB1157, 2.7 ± 0.58 for BW527, 14.0 ± 3.61 for BW9091,
3.7 ± 0.58 for BH20, 4.7 ± 0.49 for BW375. (*) p<0.05 when compared with control
group. Error bars indicate the standard deviation of the mean for n=2 independent
experiments |
