mRNA protein gene name expression after siRNA gene name expression after siRNA 14-3-3 and related genes Small GTPases and related proteins 14-3-3s ↓ Rac1/2/3 ↓ 14-3-3e → RhoA ↓ 14-3-3z → LIMK1 ↓ REC8 TV1 → Cdc42 → REC8 TV2 → cytoskeleton     phospho. cofilin ↓ cofilin ↑ acet. Tubulin → Tubulin → Cyclines cyclin A ↓ cyclin D → cyclin E ↓ Others maspin → 14-3-3s ↓

Table 2: Tabulation of investigated proteins and there regulation upon 14-3-3σ knock-down in HaCaT cells. The results were classified in ↑ (over-expression), ↓ (down-regulation) and (no regulation).