| |
Responders |
Responders with shortened period of efficacy |
Non-responders with production of antibodies |
Non-responders without production of antibodies |
| IFX |
≥ 1 |
0 – 0.5 |
0 |
≥ 1 |
| ATI |
negative |
negative |
positive |
negative |
| Clinical efficacy |
good response |
shortened period of efficacy |
shortened period of efficacy, later no response |
no response |
| Recommendation |
continue in the treatment without changes |
reduce maintenance interval to 6 weeks |
add MTX
reduce maintenance interval to 6 weeks change biological ETA > ADA or UST |
change biological - UST |
