| Adverse treatment effects |
Prednisolone (systemic) |
MMF |
IVIG |
Rituximab |
Azathioprine |
Total Patient Cases |
| Sleep Disturbance |
3 |
|
|
|
|
3 |
| Increased appetite |
4 |
|
|
|
|
4 |
| Weight gain |
3 |
|
|
|
|
3 |
| Increased BSLs |
2 |
|
|
|
|
2 |
| Lethargy |
3 |
1 |
|
|
|
4 |
| Agitation/irritability |
2 |
|
|
|
|
2 |
| Osteopaenia/osteoporosis |
9 |
|
|
|
|
9 |
| Lymphopaenia |
1 |
|
|
|
1* |
2 |
| Oral candidiasis |
7 |
|
|
|
|
7 |
| Spontaneous Ecchymoses |
2 |
|
|
|
|
2 |
| Gastric upset (nausea/vomiting/diarrhoea) |
3 |
4 |
|
|
|
7 |
| Flare of infection (orchitis, CMV, HSV) |
4 |
4 |
|
|
1 |
9 |
| Flare of Acne |
1 |
|
|
|
|
1 |
| LFT derangement |
|
2 |
|
|
|
2 |
| Shortness of Breath |
1 |
1 |
|
|
|
2 |
| Cushingoidfacies |
5 |
|
|
|
|
5 |
| Post inflammatory hyperpigmentation |
3 |
4 |
|
1 |
|
8 |
| Patient perceived effects (discomfort/distress) |
2 |
2 |
|
|
|
4 |
| Unaffordability |
|
|
|
1 |
|
1 |
| Total side effect cases for each treatment |
55 |
20 |
|
2 |
|
77 |
| Total patients (receiving treatment for pemphigus vulgaris) |
21 (n) |
17 |
2 |
7 |
|
|
|
n= total sample of patients with biopsy proven pemphigus vulgaris |
| *severe life threatening lymphopaenia (<0.2) with reduced T- cell subsets (CD4 and CD8 counts) for single case of MMF tx |
|
|
