aOne publication (Hill 1979) reported separate data for two trials (COG 7131 trial and COG 7131A trial), each was extracted as a separate study; EMA: European Medicines Agency; FDA: Food and Drug Administration; ITC: Indirect Treatment Comparison; nRCT: Non-Randomized Controlled Trial; RCT: Randomized Controlled Trial

Figure 1: Study identification, screening, and eligibility.