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Figure 1: Gross view of hair growth on the dorsal surface of individual mice. Response to treatment in animals with the least hair loss at initial dosing: shown are outcomes of vehicle or PTHCBD treated animals (at the indicated doses) which had the least amount hair loss at the start of the study. (A) The vehicle treated animal showed expected hair loss. (B) PTH-CBD treated animals had little or no hair loss. (C) Response to treatment in animals with the most hair loss at the start of the study: Shown are outcomes of animals receiving either vehicle or PTH-CBD (1000 μg/kg, x1 or weekly as indicated) housed in the same cage. Note that the vehicle treated animal showed significantly more hair loss. (D) Hair loss followed by regrowth in PTH-CBD treated animals: Shown are photographs of the same animal at different time points, with evidence of hair loss events followed by regrowth, from the groups receiving PTH-CBD (1000 ug/kg x1 or weekly as indicated). |