Table 1

		Sequence 1 with intervening blue light	Sequence 2 With intervening red light	P-value diff% in sequence 1 compared diff% in sequence 2
Light adapted	Blue _reference mean (95% CI)	AUC 16.63 15.93 – 17.33	AUC 16.52 15.94 – 17.09
	Blue _Test mean (95% CI)	AUC 17.40 16.70 – 18.11	AUC 17.08 16.59 – 17.55
	Blue_Test- Blue_Reference mean (95%Cl)	diff % 4.7 2.1 - 7.4	diff% 3.4 1.0 - 5.9	0.39
Dark adapted	Blue _Reference mean (95% CI)	AUC 15.63 14.97 – 16.30	AUC 15.46 14.50 – 16.43
	Blue_test mean (95% CI)	AUC 17.04 16.37 – 17.72	AUC 17.04 16.39 – 17.69
	Blue_Test- Blue_Reference mean 95 %Cl	diff% 9.2 5.0 – 13.3	diff% 10.7 4.3 – 17.1	0.58

Table 1: AUC results. Pupil response to the reference and the test blue stimulus for 2 light sequences The area under the curve (AUC) of the pupillary response (mean and 95 % Cl) is shown in the upper part of the table for the light adapted and in the lower part of the table for the dark adapted state. Sequence 1 refers to a triplet of 3 successive, equiluminant blue light exposures and sequence 2 refers to a similar triplet of light stimulation, except that the intervening (middle) exposure is a red light of similar intensity. For simplicity, only data from the reference and test stimuli are shown. Results are given as the relative difference between the reference and test stimuli for each sequence (diff%). P-values are calculated with a paired t-test comparing the relative difference with intervening blue light and intervening red light.