Patients with
asynchronous bilateralization
(n = 3)
Total
(n = 18)
Metastatic disease
No.
%
No.
%
No
%
No
%
Optic nerve invasion
Not invaded
7
46.7
1
33.3
8
44.5
1
12.5
Invaded
Not reach resection margin
5
33.3
1
33.3
6
33.3
2
33.3
Reach resection margin
3
20
1
33.4*
4
22.2
3
75**
Total
15
100
3
100
18
100
6
33.3
Tumor differentiation
Well differentiated
11
73.3
2
66.7
13
72.2
2
15.4
Poorly differentiated
4
26.7
1
33.3*
5
27.8
4
80**
Total
15
100
3
100
18
100
6
33.3
Tumor histogenesis
Positive (NSE)
8
53.3
1
33.3
9
50
2
20.2
Negative (NSE)
7
46.7
2
66.7***
9
50
4
40.4
Total
15
100
3
100
18
100
6
33.3
*A nonsignificant statistical correlation was found between optic nerve invasion/
tumor differentiation and asynchronous bilateralization of retinoblastoma (P > 0.05)
**A statistically significant correlation was found between optic nerve invasion
reaching the resection margin/poor tumor differentiation and metastatic disease of
retinoblastoma (P < 0.05)
***A statistically significant correlation was found between negative neuron-specific
enolase (NSE) staining and asynchronous bilateralization of retinoblastoma (P <
0.05)
Table 3: Correlation between Tumor Characteristics (Optic Nerve Invasion, Tumor
Differentiation, and Tumor Histogenesis) and Asynchronous Bilateralization of
Retinoblastoma or Metastatic Disease.
