Formulation Code

Permeability Coefficient (cm.hr^-1) (*10^-3)

Steady-State Flux (µg.cm^-2.hr^-1)

F3: HPC 10%, ERL100 2% at the ratio (5:1)

7.8279

2.778

F4: HPC 10%, ERL100 2% at the ratio (2:1)

5.444

1.64

F7: MC 5%,  ERL100 5%  at the ratio  (1:1)

10.4

2.865

F8: MC5%, ERL100 5% at the ratio (1:3)

9.30

3.041

F12: HPC 10%, EC 2% at the ratio (15:1)

10.06

3.0007

Marketed eye drops

68.19

20.458