Figure 3: Group Controls. In group control experiments, DKOrd8 and C57BL/6 (WT) mice are ramdomized by weight and separated into treatment or control groups. The 4 groups of mice are followed by fundoscopy for certain duration (usually 2-3 months), then sacrificed, and the retinal samples are analyzed for AMD biomarkers including A2E levels, histopathology, and quantification of various mRNA transcripts. (blue eyes, received treatment; red eyes, controls that received placebo or left untreated)