Mouse Strain DKOrd8 Ccl2-/-/Cx3cr1-/-/Crb1rd8 DKO Ccl2-/-/Cx3cr1-/-Crb1+/+ Crb1rd8 C57BL/6N (Crb1rd8background) Rd8Retinal Degeneration + - + + (rare) AMD-like Retinal Degeneration         Onset 2-6 weeks 12 months 2-3 months 2-3 months Spontaneous + - + - Photoreceptor Shortening ++ + (induced) + (late) - RPE Degeneration + + (induced) - - Elevated A2E + - - - Macrophage Infiltration ++ + (late) - - Complement Deposition ++ ++ (late) - - References [6,8] [22] [6] [6,20]

Table 1: Retinal degeneration and immune activation in DKOrd8, DKO, Crb1rd8, and C57BL/6N (with Crb1rd8 background) strains.