drug |
references |
No. of strains |
Method |
Incubation time (hours) |
MIC, μg/ml |
Range |
geometric mean |
50 |
90 |
Albaconazole |
[11] |
13 |
M38-P |
48 |
0.03-1 |
0.13 |
0.125 |
1 |
|
[11,12] |
24 |
M38-P |
72 |
0.06-2 |
0.41-1 |
0.5-1 |
1-2 |
Amphotericin |
[13,14] |
20 |
E-test |
48 |
2->32 |
- |
>32 |
8,>32 |
|
[14] |
10 |
E-test |
72 |
4-8 |
6.7 |
- |
8 |
|
[13,15] |
37 |
M27-A |
48 |
1->16 |
4 |
2-4 |
8->16 |
|
[16,17] |
122 |
M38-A |
48 |
0.5-16 |
- |
4.0 |
8.0->16 |
|
[11] |
13 |
M38-P |
48 |
0.5-8 |
1.72 |
2 |
4 |
|
[11,12,14,18] |
51 |
M38-P |
72 |
1->16 |
2.97-4 |
4 |
>1->16 |
|
[19] |
26 |
- |
- |
1-6 |
4.56 |
4 |
8 |
|
[20] |
10 |
Sensititre |
72 |
2->16 |
- |
- |
4 |
Fluconazole |
[20] |
10 |
Sensititre |
72 |
16-≥256 |
- |
- |
≥256 |
|
[15] |
27 |
M27-A |
48 |
16->16 |
>16 |
>16 |
>16 |
|
[18] |
17 |
M38-P |
72 |
8->64 |
- |
16 |
32 |
Itraconazole |
[16,17,21] |
176 |
M38-A |
48 |
0.03–>8.0 |
- |
0.5, ≥ 8.0 |
1.0, ≥8.0 |
|
[20] |
10 |
Sensititre |
72 |
0.5-≥16 |
- |
- |
≥16 |
|
[19] |
26 |
- |
- |
0.125-2 |
0.65 |
0.5 |
2 |
|
[13,15] |
37 |
M27-A |
48 |
0.25-16 |
- |
1, 8 |
2, 16 |
|
[13,14] |
20 |
E-test |
48 |
0.25->32 |
- |
- |
0.5, >32 |
|
[14] |
10 |
E-test |
72 |
0.25-0.5 |
0.4 |
- |
0.5 |
|
[11] |
13 |
M38-P |
48 |
0.03-2 |
0.35 |
0.5 |
2 |
|
[11,12,14,18] |
51 |
M38-P |
72 |
0.03->16 |
0.78-4.5 |
0.5->16 |
1->16 |
|
[22] |
6 |
- |
- |
0.12->64 |
- |
- |
- |
Ketoconazole |
[20] |
10 |
Sensititre |
72 |
0.25-≥16 |
- |
- |
≥16 |
|
[15] |
27 |
M27-A |
48 |
0.06->16 |
2 |
2 |
>16 |
|
[12] |
11 |
M38-P |
72 |
4-16 |
10.07 |
16 |
>16 |
Liposomal nystatin |
[11] |
13 |
M38-P |
48 |
2-16 |
5.99 |
4 |
16 |
|
[11] |
13 |
M38-P |
72 |
4-16 |
11.99 |
16 |
16 |
Miconazole |
[15] |
27 |
M27-A |
48 |
0.06-4 |
0.5 |
0.5 |
2 |
|
[11] |
13 |
M38-P |
48 |
0.125 |
0.34 |
0.25 |
1 |
|
[11,18] |
30 |
M38-P |
72 |
≤0.06-1 |
- |
0.25-0.5 |
0.5-1 |
Micafungin |
[23] |
3 |
M38-A |
24 |
0.25-128 |
- |
32 |
- |
|
[18] |
17 |
M38-P |
72 |
16->16 |
- |
>16 |
>16 |
Nystatin |
[11,12] |
24 |
M38-P |
72 |
4-32 |
12.70-13.24 |
4-16 |
≥16 |
|
[11] |
13 |
M38-P |
48 |
2-16 |
5.99 |
- |
- |
Posaconazole |
[19] |
20 |
- |
- |
0.25-1.0 |
0.57 |
0.5 |
1 |
|
[17] |
65 |
M38-A |
48 |
- |
- |
1.0 |
8.0 |
|
[11] |
13 |
M38-P |
48 |
0.125-1 |
0.42 |
0.5 |
1 |
|
[11,12] |
24 |
M38-P |
72 |
0.03-2 |
0.08-0.79 |
0.03-1 |
0.25-2 |
Ravuconazole |
[21] |
54 |
M38-A |
48 |
0.5->8.0 |
3.8 |
4.0 |
>8.0 |
|
[12] |
11 |
M38-P |
72 |
0.125 |
0.125 |
0.125 |
0.125 |
Terbinafine |
[19] |
5 |
- |
- |
32 |
32 |
32 |
32 |
|
[24] |
31 |
M38-A |
48 |
8->16 |
17.1 |
- |
>16 |
|
[11] |
13 |
M38-P |
48 |
2->32 |
32 |
32 |
>32 |
|
[11] |
13 |
M38-P |
72 |
32->32 |
>32 |
>32 |
>32 |
Voriconazole |
[16,17,21] |
176 |
M38-A |
48 |
0.06–4.0 |
- |
0.25-1.0 |
0.25-4.0 >8.0 |
|
[19] |
26 |
- |
- |
0.06-1.0 |
0.22 |
0.25 |
0.25 |
|
[15] |
27 |
M27-A |
48 |
0.5-2 |
1 |
1 |
2 |
|
[23,25] |
9 |
M38-A |
72 |
0.125-1.0 |
- |
0.125-0.5 |
0.25-1 |
|
[11,12,18] |
44 |
M38-P |
72 |
0.01-0.5 |
0.06-0.17 |
0.06-0.25 |
0.125-0.5 |
|
[11] |
13 |
M38-P |
48 |
0.03-0.5 |
0.09 |
0.125 |
0.25 |
|
[22] |
6 |
- |
- |
0.12-0.5 |
|
|
|
|
[25] |
6 |
Sensititre |
72 |
1 |
- |
0.5 |
0.5 |
5-Fluorocytosine |
[20] |
10 |
Sensititre |
72 |
4-≥64 |
- |
- |
≥64 |
|
[15] |
27 |
M27-A |
48 |
>16 |
>16 |
>16 |
>16 |
|
[18] |
17 |
M38-P |
72 |
8->64 |
- |
16 |
32 |
|