Cytokines
Endophthalmitis (mean + SEM)
Controls (mean + SEM)
p Value
RD (N=17)
MH/ERM (N=7)
DR (N=15)
IL-1ra
774.0 ± 245.6
12.2 ± 2.9 *
3.8 ± 0.8 *
8.6 ± 1.3 *
<0.0001
IL-2
9.7 ± 1.2
1.3 ± 0.1 *
0.6 ± 0.2 *
1.9 ± 0.3 *
<0.0001
IL-4
1.3 ± 0.2
0.3 ± 0.2 *
0.1 ± 0.0 *
0.2 ± 0.0 *
<0.0001
IL-5
1.0 ± 0.4
0.4 ± 0.1
0.3 ± 0.0
0.8 ± 0.2
0.1764
IL-6
3158.3 ± 28.9
151.1 ± 69.1 *
8.0 ± 3.8 *
72.8 ± 20.4 *
<0.0001
IL-7
5.1 ± 1.0
8.2 ± 1.6
3.8 ± 1.0
13.0 ± 2.2 *
0.0013
IL-8
5022.5 ± 1305.5
24.9 ± 5.0 *
8.5 ± 2.1 *
49.8 ± 11.4 *
<0.0001
IL-9
13.7 ± 1.9
4.0 ± 0.5 *
2.5 ± 0.6 *
8.5 ± 1.6
<0.0001
IL-10
66.0 ± 17.8
2.2 ± 0.5 *
0.7 ± 0.1 *
15.7 ± 4.1
<0.0001
IL-12p70
31.9 ± 12.0
12.4 ± 4.8
0.5 ± 0.1 *
112.1 ± 31.7
<0.0001
Il-13
6.3 ± 1.5
3.3 ± 0.9
0.9 ± 0.1 *
11.6 ± 2.9
0.0002
Il-15
9.9 ± 1.3
5.8 ± 1.2
3.0 ± 0.5 *
5.9 ± 0.7
0.0018
IL-17
89.7 ± 56.5
3.4 ± 0.4 *
2.8 ± 0.8 *
2.8 ± 0.3 *
<0.0001
Eotaxin
34.3 ± 3.9
6.5 ± 1.0 *
6.0 ± 0.6 *
11.8 ± 2.2 *
<0.0001
β-FGF
26.6 ± 13.8
39.3 ± 13.2
1.5 ± 0.4 *
3.6 ± 0.6 *
<0.0001
G-CSF
6906.8 ± 847.6
20.5 ± 9.2 *
5.9 ± 1.0 *
11.5 ± 6.3 *
<0.0001
GM-CSF
66.9 ± 9.6
33.5 ± 3.0 *
33.1 ± 6.1 *
36.9 ± 4.0 *
0.0002
IFN-γ
98.3 ± 12.1
16.3 ± 3.5 *
2.7 ± 0.7 *
46.1 ± 10.7 *
<0.0001
MCP-1
4498.5 ± 1428.4
1035.4 ± 291.3
256.5 ± 66.0 *
918.4 ± 138.2
0.0006
MIP-1α
74.1 ± 27.8
1.2 ± 0.3 *
0.3 ± 0.0 *
1.0 ± 0.1 *
<0.0001
MIP-1β
231.9 ± 64.2
15.2 ± 2.4 *
4.0 ± 0.9 *
12.1 ± 1.7 *
<0.0001
PDGF
30.8 ± 4.8
10.1 ± 3.7 *
2.7 ± 0.5 *
10.4 ± 2.1 *
<0.0001
RANTES
18.8 ± 5.1
20.7 ± 12.3
1.0 ± 0.2 *
13.6 ± 7.0
<0.0001
TNF-α
49.1 ± 5.9
3.4 ± 0.6 *
3.3 ± 0.6 *
4.2 ± 0.8 *
<0.0001
VEGF
491.7 ± 251.6
116.5 ± 49.0
3.7 ± 0.9 *
1199.1 ± 395.3 *
<0.0001
* Significantly different compared to the group with endophthalmitis (
p
< 0.05)
Table 3:
Cytokine concentrations (pg/ml) in the endophthalmitis and each control subgroup according to diagnosis.
