Figure 1: Corneal change after severe alkaline burn. A. A 53 years old male suffered from severe alkaline burn, with 360 degrees of limbal ischemia and extensive corneal and conjunctival epithelial defect. Hypopyon and exudative membrane in front of the lens were seen due to severe inflammation. B. One and a half month after injury, reepithelialization was seen from 4 and 8 O/C limbal region, accompanied by vascular ingrowth. C. Three months after injury, although corneal epithelial defect decreased significantly, corneal neovascularization progressed further. D. Four months after injury, neovascularization accelerated that blood vessels now invaded from all directions of the limbus, one of the hall mark of total limbal stem cell deficiency.