Expression vector Reference
Soluble variant of the VEGF receptor (sFlt-1) [98,99]
Tissue inhibitor of metalloproteinase-3 (TIMP-3) [101]
Endostatin [100,104]
Angiostatin [103]
Vasohibin-1 [102]
Antisense oligonucleotides
Vascular endothelial grwoth factors (VEGF) [97]
Insulin receptor substrate 1 (IRS-1) [95]
Silence-RNA
VEGF-A [113-115]
VEGF Receptor-1
VEGF Receptor-2
Hypoxia inducible factor-1 (HIF-1α) [42]
Micro-RNA
miR-31, miR -150, miR -184 [122]
miR-132 [125]
miR-204 [124]
miR-210 [122]
Table 1: Pre-clinical trials of new nucleotide-base drugs for antiangiogenesis.