s   CHR Coats disease von Hippel-Lindau disease Sex No sex predilection Male: female=3:1 No sex predilection Average age at diagnosis 25 years old 10 years old 25 years old Family history 20% No Yes Affected eye 92% unilateral 95% unilateral 45% unilateral Symptom Usually asymptomatic Decreased visual acuity Leukocoria Strabismus Decreased visual acuity Fundus finding 1. Clusters of thin-walled saccular aneurysms filled with dark venous blood isolated from the vascular tree 2. White fibroglial tissue on the surface of the tumor. 1. The aneurysms  placed along retinal vessels, 2. Progressive vascular dilatation 3. Massive intraretinal and subretinal exudation 4. Subretinal fluid Progressive dilation of the afferent and efferent feeder vessels Large isolated angioma Exudation Retinal vascular circulation Normal Aberrant arteriovenous communicating channels Abnormal feeder vessels, dilated capillary bed around the tumor Retinal exudation Rare Common and progressive Common, may progressive Retinal detachment Rare, proliferative Sometimes, exudative Sometimes, proliferative FFA Plasma-erythrocytic separation; No leakage Capillary nonperfusion Leakage from the lesion Slow retinal circulation; Leakage from angioma Progress Usually stable Progress Progress Visual prognosis Good Poor Poor Treatment Observation Photocoagulation Cryotherapy Photocoagulation Cryotherapy

Table 2: Differential diagnosis of CHR with Coats disease and von Hippel-Lindau disease.