| Traditional
                anaesthetic 
          agents:  | 
         Type | 
         Onset | 
        Potency | 
        Toxicity | 
        Duration | 
      
      
        | Procaine
          2-chloroprocaine
          Tetracaine
          (Amethocaine)
          Cocaine | 
         Ester
           Ester
           Ester
          
          Ester | 
         Slow
           Rapid
           Slow
           
          Slow | 
        Low
          Intermediate
          Intermediate
           
          High  | 
        Low
          Low
          Intermediate
          
          
          Very High | 
        Short
          Short
          Intermediate
          
          
          Long | 
      
      
        | Benoxinate
          (oxybuprocaine) | 
        Ester | 
        It must be    used in lowest possible dosa
          ge [36] to avoid:
          i) lethal    reactions in low cholinesterase activities
          ii) allergy to    the para-aminobenzoic moities
          iii)    absorption through nasal-lacrimal apparatus or mucous membrane | 
      
      
        | Bupivacaine
          Lidocaine
          Ropivacaine
          Etidocaine | 
        Amide Amide
          Amide
          Amide | 
        Slow
          Rapid
          Slow
          Rapid | 
        High 
          Intermediate
          Intermediate
          High | 
        High
          Low
          Intermediate
          High | 
        Long
          Short
          Long
          Long | 
      
      
        | Newly    developed
                anaesthetic 
          agents  | 
      
      
        | Articaine
          Levobupivacaine 
          2-Choloroprocaine 
          Proxymethacaine | 
        Amide Amide
          Ester Ester | 
        Rapid Slow
          Rapid Rapid | 
          | 
        Low 
          High 
          Low 
          Low | 
        Long
          Long 
          Short
          Intermediate |