Polymeric formulation D/r2 × 107  (1/s) Dmina × 1016 (cm2/s) Dmaxb × 1016 (cm2/s) R2 100% PLA 4.38 0.98 8.88 0.964 100% PLGA 15.51 3.49 31.41 0.898 100% PCL 4.37 0.98 8.84 0.951 100% Eudragit® RS100 4.80 1.08 9.73 0.943 25% PLGA-75% PLA 4.56 1.03 9.25 0.958 30% PLGA-70% PLA 3.86 0.87 7.81 0.979 35% PLGA-65% PLA 3.50 0.77 7.08 0.971 40% PLGA-60% PLA 3.76 0.85 7.62 0.973 45% PLGA-55% PLA 3.70 0.83 7.50 0.967 50% PLGA-50% PLA 3.76 0.84 7.61 0.974 55% PLGA-45% PLA 3.66 0.82 7.41 0.969 60% PLGA-40% PLA 7.55 1.70 15.29 0.952 65% PLGA-35% PLA 11.64 2.62 23.58 0.929 70% PLGA-30% PLA 12.06 2.71 24.42 0.922 75% PLGA-25% PLA 14.35 3.23 29.06 0.893 25% PCL-75% Eudragit® RS100 4.77 1.07 9.66 0.948 50% PCL-50% Eudragit® RS100 4.05 0.91 8.20 0.948 75% PCL-25% Eudragit® RS100 4.53 1.02 9.17 0.946 80% PLGA/PLA (45/55)-20% PCL 3.82 0.86 7.73 0.943 60% PLGA/PLA (45/55)-40% PCL 17.26 3.88 34.95 0.876 40% PLGA/PLA (45/55)-60% PCL 4.94 1.11 10.00 0.945 20% PLGA/PLA (45/55)-80% PCL 4.71 1.06 9.54 0.942 80% PLGA/PLA (45/55)-20% Eudragit® RS100 11.93 2.68 24.16 0.918 60% PLGA/PLA (45/55)-40% Eudragit® RS100 5.82 1.31 11.78 0.931 40% PLGA/PLA (45/55)-60% Eudragit® RS100 10.58 2.38 21.42 0.921 20% PLGA/PLA (45/55)-80% Eudragit® RS100 71.75 16.14 145.29 0.953 33% PLGA-33% PLA-33% Eudragit® RS100 5.49 1.24 11.13 0.947 33% PLGA-33% PLA-33% PCL 4.79 1.08 9.70 0.922 33% PLGA-33% Eudragit® RS100-33% PCL 6.62 1.49 13.41 0.912 33% PLA-33% Eudragit® RS100-33% PCL 7.82 1.76 15.84 0.948 25% PLGA-25% PLA-25% Eudragit® RS100-25% PCL 4.80 1.08 9.71 0.939

aCalculated based on Diametermin=300 nm bCalculated based on Diametermax=900 nm

Table 7: Diffusion coefficients and the correlation coefficient values for different formulations.