| Summary of different EpCAM-based CTC isolation approaches |
| Isolation process |
Advantages |
Disadvantages |
References |
| CellSearch |
High sensitivity
CTC quantification |
Subjective images interpretation
no further analysis possible |
[33] |
| CTC Chip |
98% cell viability
high identification rate
further analysis possible |
lack of validation studies
in clinical settings
not commercially available |
[34] |
| MagSweeper |
high degree of purity
further analysis possible |
not commercially available |
[35] |
Nanostructured
Substrates |
increasing cell-substrate contact
frequency & high affinity |
not commercially available |
[36] |
