Index Water loading Loading with 0.1 % natrium chloride solution Loading with 0.25 % natrium chloride solution Loading with 0.5 % natrium chloride solution n1 = 14 n = 10 n = 11 n = 24 Diuresis, ml/per hour 174 ± 33 177 ± 37 143 + 33 158 ± 19 Relative dieresis, % 55.8 + 11.4 53.8 + 9.1 43.3 + 9.6 49.2 + 6.2 Urine creatinine, mmol/l 7.9 ± 1.5 5.2 ± 1 12.3 ± 3.5 12.5 ± 1.7 p2 = 0.05 Excretion of creatinine, mmol/per hour 1.1 ± 0.2 0.8 ± 0.1 0.9 ± 0.1 1.8 ± 0.2 p < 0.05 Osmolality of urine, mosmol/kg 379 ± 45 397 ± 81 569 ± 106 p < 0.05 617 ± 58 p < 0.05 Excretion of osmotically active substances, mosmol/ per hour 62.9 ± 11.5 58. 3 ± 8.9 56.6 ± 8.1 85.9 ± 9 Standardized excretion of osmotically active substances (mosmol/mmol of creatinine per 70 kg of body mass) 58.3 ± 5.5 84.2 ± 9.9 p< 0.05 78.5 ± 20.1 56.7 ± 3.2 1n – number of observations 2p – true index of differences in comparison with water loading.

Table 1: Functional urine condition of healthy volunteers at water and hydrosaline loading in 0.5 % of the body mass (X ± m).