| |
Control
Insulin |
Ethanol Insulin |
Control IGF1 |
Ethanol IGF1
IGF1 |
Control IGF2 |
Ethanol IGF2 |
| Best-fit values |
|
|
|
|
|
|
| Bmax |
4.92 ± 0.82 |
3.01 ± 0.41* |
11.56 ±0.99 |
8.6 ± 0.87** |
25.3 ± 3.25 |
25.06 ± 2.19 |
| Kd |
4.06 ± 1.01 |
2.33 ± 0.55 |
1.17 ± 0.26 |
0.99 ± 0.28 |
1.89 ± 0.51 |
2.56 ± 0.43 |
| Bmax [95% CIL] |
3.29-6.63 |
2.19-3.83 |
9.54-13.58 |
6.85-10.39 |
18.73-31.88 |
20.63-29.48 |
| Kd [95% CIL] |
2.01-6.11 |
1.22-3.45 |
0.64-1.70 |
0.42-1.55 |
0.85-2.93 |
1.72-3.47 |
| Goodness of fit |
|
|
|
|
|
|
| R-square |
0.931 |
0.903 |
0.882 |
0.820 |
0.851 |
0.940 |
Bmax=Top-level binding; Kd=binding affinity constant; CIL= confidence interval limits
*Inter-group statistical comparisons for insulin receptor binding: Bmax, P=0.017; Kd, P=0.09
** Inter-group comparisons for IGF1 receptor binding: Bmax, P=0.022; Kd, P=0.60 |
