| Histological features |
Classification |
Description |
Frequencies, n (%) |
| Necroses |
0) None
1) Small
2) Large
3) Large and small |
Areas with necrotic morphology |
0) 3/200 (1.5 %)
1) 34/200 (17.0 %)
2) 56/200 (28.0 %)
3) 107/200 (53.5 %) |
| Apoptoses |
|
Apoptotic figures |
200/200 (100.0 %) |
| Mitoses |
Number of mitotic figures in 10 consecutive high power fields (HPFs) |
Counted in the most proliferative active areas with the 40x objective (HPF) |
Median: 8.5
Mean: 12.8
Range: 0 – 64
≥1 mitosis: 192/200 (96 %)
None: 8/200 (4.0 %) |
| Microvascular proliferation |
1) Glomeruloid tufts
2) Endothelial proliferation
3) Both
4) None |
Present or not present, in the tumour centre and the infiltrating front |
1)130/200 (65.0 %)
2) 164/200 (82.0 %)
3) 136/200 (63.0 %)
4) 31/200 (15.5 %) |
| Cell types |
1) Gemistocytes
2) Small cells
3) Spindle cells
4) Epitheloid cells |
When present in more than 20% of the tumour |
1) 67/200 (33.5 %)
2) 42/200 (21.0 %)
3) 19/200 (9.5 %)
5) 4/200 (2.0 %) |
| Subtypes |
1) Small cell glioblastoma
2) Giant cell glioblastoma
3) Gliosarcoma |
Tumours consisting predominantly of one cell type |
1) 14/200 (7.0 %)
2) 2/200 (1.0 %)
3) 0/200 (0.0 %) |
| Giant cells |
0) None
1) Sparsely
2) Moderate
3) Common |
Large, often multinucleated, highly atypical cells |
0) 112/200 = (56.0 %)
1) 53/200 = (26.5 %)
2) 27/200 = (13.5 %)
3) 8/200 = (4.0 %) |
| Oligodendroglioma component |
0) None
1) Present in < 20 %
2) Present in > 20 %. |
Areas of oligodendroglioma-like morphology |
0)187/200 (93.5 %)
1) 8/200 (4.0 %)
2) 5/200 (2.5 %) |
| Perivascular lymphocyte infiltration |
|
|
73/200 (36.5 %) |
| Macrophage infiltration |
|
|
52/200 (26.0 %) |
| Haemorrhages |
|
Blood degradation or haemosiderine-laden macrophages |
106/200 (53.0 %) |
| Thromboses |
|
Thrombotic occluded vessels |
157/200 (78.5 %) |
| Calcification |
|
|
24/200 (12.0 %) |
| Pseudopalisades |
|
|
158/200 (79.0 %) |
| Atypia |
1) Mild
2) Moderate
3) Severe |
|
1) 15/200 (7.5 %)
2) 134/200 (67.0 %)
3) 51/200 (25.5 %) |
| Cell density |
1) Low
2) Moderate
3) High |
|
1) 7/200 (3.5 %)
2)141/200 (70.5 %)
3) 52/200 (26.0 %) |
| Pseudorosettes |
|
|
93/200 (46.5 %) |
| Desmoplasia |
|
|
88/200 (44.0 %) |
| Nucleoli |
|
|
23/200 (11.5 %) |
| Atypical mitoses |
|
|
119/200 (59.5 %) |
| Microcysts |
|
|
58/200 (29.0 %) |
| Mucin |
|
|
66/200 (33.0 %) |
| Leptomeningeal infiltration |
|
|
45/200 (22.5 %) |
| Secondary structures of Scherer |
1) Perineural growth
2) Angiocentric growth
3) Subpial cell-clustering
4)One or more phenomena |
Assessment of Scherer phenomena was possible in 147 and 127 cases, respectively |
1) 52/147 (34.5 %)
2) 40/147 (27.2 %)
3) 20/124 (16.1 %)
4) 73/152 (48.0 %) |
