HEMATOLOGICAL Complete (CHR) Partial (PHR) WBC< 1x109/L; basophils <5%; no circulating granulocyte precursors; platelet count <450x109/L; no splenomegaly Levels less than the above CYTOGENETIC Partial (PCyR) Major (MCyR) Complete (CCyR) 1%-35% Ph1 positive metaphases Combination of PCyR and CCyR (≤35% Ph1 positive metaphases) No Ph1 positive metaphases detected in 2 successive bone marrow samples after counting 30 metaphases MOLECULAR Major (MMR) Complete (CMR) 3-log reduction in transcript level based on 2-consequtive molecular analyses 2 consecutive samples with no detectable transcripts provided that control gene copy numbers are adequate

Table 1: Definitions for hematological, Cytogenetic and Molecular remission.