| Treatment |
Control |
Ethanol |
t-statistic |
P< Value |
| Vehicle |
6.54 ± 0.59 |
11.21 ± 1.12 |
2.601 |
0.05 |
| PPAR-α |
11.27 ± 1.75 |
31.35 ± 3.06 |
12.60 |
0.0001 |
| PPAR-δ |
5.28 ± 0.53 |
7.35 ± 0.41 |
1.406 |
N.S. |
| PPAR-γ |
9.47 ± 1.07 |
14.92 ± 1.10 |
4.017 |
0.001 |
Liver tissue homogenates were analyzed for lipid content using the Nile Red
fluorometric assay. Values reflect mean ± S.E.M. fluorescence light units corrected
for protein content in the sample. 2-way ANOVA tests demonstrated significant
effects of ethanol (F=113.42; df=84; P<00001), PPAR agonist treatments (F=50.19,
df=84; P<0.0001), and interactions between ethanol exposure and PPAR agonist
treatments (F=30.56, df=84; P<0.0001). Bonferroni posttests demonstrated
significant between group differences as indicated by the t-statistic and P-value
in the Table. |
