Amph B (mcg/ml) Flucytosine (mcg/ml) Fluconazole (mcg/ml) Voriconazole (mcg/ml) Caspofungin (mcg/ml) Anidulafungin (mcg/ml) Micafungin (mcg/ml)
MIC 50% MIC 90% MIC 50% MIC 90% MIC 50% MIC 90% MIC 50% MIC 90% MIC 50% MIC 90% MIC 50% MIC 90% MIC 50% MIC 90%
C. albicans(70) 0.12 0.25 0.12 1 0.25 1 0.03 0.06 0.5 0.5 0.03 0.03 0.08 0.15
C. glabrata(28) 0.25 0.5 0.12 0.12 8 32 0.25 1 0.5 1 0.03 0.12 0.25 0.5
C. parapsilosis(34) 0.25 0.5 0.12 0.12 1 2 0.03 0.12 2 2 0.06 0.06 0.25 1
C. tropicalis(11) 0.25 0.5 0.12 0.5 0.5 16 0.06 2 0.5 0.5 0.03 0.12 0.03 0.06
C. krusei(19) 0.25 0.5 4 32 32 >64 0.5 1 1 2 0.06 0.12 0.5 1
Others (5) 0.12 0.5 0.12 0.12 0.5 4 0.03 0.25 1 2 0.06 0.25 0.03 0.03
Proposed EUCAST breakpoints of flucytosyne for C.albicans, C.tropicalis and C. parapsilosis: ≤4mcg/ml =S, 8-12mcg/ml=I, ≥32mcg/ml=R For the other antymicotic agents, EUCAST 2012 breakpoints are followed [9]
Table 3: Minimum inhibitory concentration (MIC50%/MIC90%) of antifungal agents against the 167 Candidae strains isolated.