| |
Amph B
(mcg/ml) |
Flucytosine
(mcg/ml) |
Fluconazole
(mcg/ml) |
Voriconazole
(mcg/ml) |
Caspofungin
(mcg/ml) |
Anidulafungin
(mcg/ml) |
Micafungin
(mcg/ml) |
| MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
MIC
50% |
MIC
90% |
| C. albicans(70) |
0.12 |
0.25 |
0.12 |
1 |
0.25 |
1 |
0.03 |
0.06 |
0.5 |
0.5 |
0.03 |
0.03 |
0.08 |
0.15 |
| C. glabrata(28) |
0.25 |
0.5 |
0.12 |
0.12 |
8 |
32 |
0.25 |
1 |
0.5 |
1 |
0.03 |
0.12 |
0.25 |
0.5 |
| C. parapsilosis(34) |
0.25 |
0.5 |
0.12 |
0.12 |
1 |
2 |
0.03 |
0.12 |
2 |
2 |
0.06 |
0.06 |
0.25 |
1 |
| C. tropicalis(11) |
0.25 |
0.5 |
0.12 |
0.5 |
0.5 |
16 |
0.06 |
2 |
0.5 |
0.5 |
0.03 |
0.12 |
0.03 |
0.06 |
| C. krusei(19) |
0.25 |
0.5 |
4 |
32 |
32 |
>64 |
0.5 |
1 |
1 |
2 |
0.06 |
0.12 |
0.5 |
1 |
| Others (5) |
0.12 |
0.5 |
0.12 |
0.12 |
0.5 |
4 |
0.03 |
0.25 |
1 |
2 |
0.06 |
0.25 |
0.03 |
0.03 |
Proposed EUCAST breakpoints of flucytosyne for C.albicans, C.tropicalis and C. parapsilosis: ≤4mcg/ml =S, 8-12mcg/ml=I, ≥32mcg/ml=R
For the other antymicotic agents, EUCAST 2012 breakpoints are followed [9] |
