| Type |
Patterns |
HCC (n=102) |
CH (n=105) |
P value |
| |
V1753 |
T1762 |
A1768 |
T1766 |
A1764 |
| wild-type |
- |
- |
- |
- |
- |
2 (2.0%) |
25 |
0.026 |
| single mutation |
- |
|
|
|
|
0 (0%) |
(23.8%) |
|
| double mutation |
+ |
- |
- |
- |
- |
66 (64.7%)
4 (3.9%) |
13 (12.4%) |
0.802
0.064 |
| triple mutation
|
-
- |
+
- |
+
- |
-
+ |
- |
12 (11.8%)*
6 (5.9%)
7 (6.9%)* |
54 (51.4%)
2 (1.9%) |
0.022
0.092
0.039 |
| quadruple mutation |
+
+
-
-
+
-
|
+
+
+
+
+
|
+
+
+
+
+ |
-
+
-
-
+ |
-
-
+
+
+ |
3 (2.9%)*
2 (2.0%) |
4 (3.8%)
5 (4.8%)
3 (2.9%)
1 (0.95%)
0 (0%) |
0.041 |
HCC: Hepatocellular Carcinoma; CH: Chronic Heptitis *P<0.05 comparing the frequency of triple mutation or quadruple mutation in HCC vs.CH. |
