Figure 2: Normal appearance of the pancreas is distorted (a and b, white asterisks). Severe inflammation is present between fibrotic pancreatic tissue and cyst lumen (a and b white arrows).This inflammation consists of lymphocytes, necrotic debris and giant cells (a-d). The multinucleated giant cells are observed in many areas of inflammation at the vicinity of the cyst wall (b-d). A larger view of the area marked by black rectangle in c reveals multinucleated giant cells in the inflammatory infiltrate in d. These cells are strongly positive with CD68 supporting their inflammatory origin (e).In some areas fragment of cuticular membrane is observed upon inflammatory infiltrate and in cyst lumen (b, g and arrowhead in f). This membrane displays the laminated layer as a narrow band (long arrows in b and g). The germinal layer is marked by short arrows (b and g).